Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumour microenvironment and cross-resistance to immunotherapy in melanoma

How targeted therapies and immunotherapies shape tumours and thereby influence subsequent therapeutic responses is poorly understood. Here, we show in melanoma patients and mouse models that when tumours relapse following targeted therapy with MAPK pathway inhibitors, they are cross-resistant to imm...

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Veröffentlicht in:Nat Cancer
Hauptverfasser: Haas, Lisa, Elewaut, Anais, Gerard, Camille L., Umkehrer, Christian, Leiendecker, Lukas, Pedersen, Malin, Krecioch, Izabela, Hoffmann, David, Novatchkova, Maria, Kuttke, Mario, Neumann, Tobias, de Silva, Ines Pires, Witthock, Harriet, Cuendet, Michel A., Carotta, Sebastian, Harrington, Kevin J., Zuber, Johannes, Scolyer, Richard A., Long, Georgina V., Wilmott, James S., Michielin, Olivier, Vanharanta, Sakari, Wiesner, Thomas, Obenauf, Anna C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613740/
https://ncbi.nlm.nih.gov/pubmed/35121945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-021-00221-9
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