Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumour microenvironment and cross-resistance to immunotherapy in melanoma

How targeted therapies and immunotherapies shape tumours and thereby influence subsequent therapeutic responses is poorly understood. Here, we show in melanoma patients and mouse models that when tumours relapse following targeted therapy with MAPK pathway inhibitors, they are cross-resistant to imm...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Cancer
Main Authors: Haas, Lisa, Elewaut, Anais, Gerard, Camille L., Umkehrer, Christian, Leiendecker, Lukas, Pedersen, Malin, Krecioch, Izabela, Hoffmann, David, Novatchkova, Maria, Kuttke, Mario, Neumann, Tobias, de Silva, Ines Pires, Witthock, Harriet, Cuendet, Michel A., Carotta, Sebastian, Harrington, Kevin J., Zuber, Johannes, Scolyer, Richard A., Long, Georgina V., Wilmott, James S., Michielin, Olivier, Vanharanta, Sakari, Wiesner, Thomas, Obenauf, Anna C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613740/
https://ncbi.nlm.nih.gov/pubmed/35121945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-021-00221-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados