The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

Co-translational folding is crucial to ensure the production of biologically active proteins. The ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural understanding remains largely inaccessible experimentally. We have developed site-specific labelling of nascent ch...

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Pubblicato in:Nat Chem
Autori principali: Chan, Sammy H. S., Włodarski, Tomasz, Streit, Julian O., Cassaignau, Anaïs M. E., Woodburn, Lauren F., Ahn, Minkoo, Freiherr von Sass, Georg Johannes, Waudby, Christopher A., Budisa, Nediljko, Cabrita, Lisa D., Christodoulou, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2022
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613651/
https://ncbi.nlm.nih.gov/pubmed/35927328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-022-01004-0
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