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The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

Co-translational folding is crucial to ensure the production of biologically active proteins. The ribosome can alter the folding pathways of nascent polypeptide chains, yet a structural understanding remains largely inaccessible experimentally. We have developed site-specific labelling of nascent ch...

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Bibliografiske detaljer
Udgivet i:Nat Chem
Main Authors: Chan, Sammy H. S., Włodarski, Tomasz, Streit, Julian O., Cassaignau, Anaïs M. E., Woodburn, Lauren F., Ahn, Minkoo, Freiherr von Sass, Georg Johannes, Waudby, Christopher A., Budisa, Nediljko, Cabrita, Lisa D., Christodoulou, John
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2022
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613651/
https://ncbi.nlm.nih.gov/pubmed/35927328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-022-01004-0
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