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Deazaflavin inhibitors of TDP2 with cellular activity can affect etoposide influx and/or efflux
Tyrosyl DNA phosphodiesterase 2 (TDP2) facilitates the repair of topoisomerase II (TOP2)-linked DNA double-strand breaks and as a consequence is required for cellular resistance to TOP2 “poisons”. Recently, a deazaflavin series of compounds were identified as potent inhibitors of TDP2, in vitro. Her...
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| Udgivet i: | ACS Chem Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7613159/ https://ncbi.nlm.nih.gov/pubmed/31091068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00144 |
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