The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Although cytokine-mediated expansion of human hematopoietic stem cells (HSCs) can result in high yields of hematopoietic progenitor cells, this generally occurs at the expense of reduced bone marrow HSC repopulating ability, thereby limiting potential therapeutic applications. Because bromodomain-co...

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Bibliographic Details
Published in:Blood
Main Authors: Hua, Peng, Hester, Joanna, Adigbli, George, Li, Rong, Psaila, Bethan, Roy, Anindita, Bataille, Carole J. R., Wynne, Graham M., Jackson, Thomas, Milne, Thomas A., Russell, Angela J., Davies, James, Roberts, Irene, Issa, Fadi, Watt, Suzanne M.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613118/
https://ncbi.nlm.nih.gov/pubmed/32599615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005357
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