A genome-wide screen uncovers broad roles for mitochondrial nucleoside diphosphate kinases in inflammasome activation

Non-canonical inflammasome activation by cytosolic LPS is a critical component of the host response to Gram-negative bacterial infection, however we lack a comprehensive understanding of the cellular processes that control this pathway. Using a genome-scale arrayed siRNA screen to discover inflammas...

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Publicado en:Sci Signal
Main Authors: Ernst, Orna, Sun, Jing, Lin, Bin, Banoth, Balaji, Dorrington, Michael G., Liang, Jonathan, Schwarz, Benjamin, Stromberg, Kaitlin, Katz, Samuel, Vayttaden, Sharat J., Bradfield, Clinton J., Slepushkina, Nadia, Rice, Christopher M., Buehler, Eugen, Khillan, Jaspal S., McVicar, Daniel W., Bosio, Catharine M., Bryant, Clare E., Sutterwala, Fayyaz S., Martin, Scott, Lal-Nag, Madhu, Fraser, Iain D.C.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613020/
https://ncbi.nlm.nih.gov/pubmed/34344832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abe0387
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