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Confounding role of tumor necrosis factor in cryopyrin-associated periodic syndromes
The NLRP3 inflammasome is a critical component of the innate immune system and can be activated in response to microbial and endogenous danger signals. Activation of the NLRP3 inflammasome results in caspase-1–dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function mis...
Guardat en:
| Publicat a: | J Clin Invest |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5707140/ https://ncbi.nlm.nih.gov/pubmed/29130931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98322 |
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