Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity

Helios, a member of the Ikaros family of transcription factors, is predominantly expressed in developing thymocytes, activated T cells, and regulatory T cells (T(regs)). Studies in mice have emphasized its role in maintenance of T(reg) immunosuppressive functions by stabilizing Foxp3 expression and...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Shahin, Tala, Kuehn, Hye Sun, Shoeb, Mohamed R., Gawriyski, Lisa, Giuliani, Sarah, Repiscak, Peter, Hoeger, Birgit, Petronczki, Özlem Yüce, Bal, Sevgi Köstel, Zoghi, Samaneh, Dmytrus, Jasmin, Seruggia, Davide, Castanon, Irinka, Rezaei, Nima, Varjosalo, Markku, Halbritter, Florian, Rosenzweig, Sergio D., Boztug, Kaan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612971/
https://ncbi.nlm.nih.gov/pubmed/34826259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abe3981
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