Methylation of histone H3 at lysine-37 by Set1 and Set2 prevents spurious DNA replication

DNA replication initiates at genomic locations known as origins of replication, which, in S. cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free, origins of replication are greatly influenced by the surrounding chromatin state. Here, we show that histone H3 lysine...

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Udgivet i:Mol Cell
Main Authors: Santos-Rosa, Helena, Millan-Zambrano, Gonzalo, Han, Namshik, Leonardi, Tommaso, Klimontova, Marie, Nasiscionyte, Simona, Pandolfini, Luca, Tzelepis, Kostantinos, Bartke, Till, Kouzarides, Tony
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612968/
https://ncbi.nlm.nih.gov/pubmed/33979575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.021
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