Promoter-bound METTL3 maintains myeloid leukaemia via m6A-dependent translation control

N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding1 and non-coding RNAs2,3, catalysed by the METTL3/METTL14 methyltransferase complex4. Here we define a novel pathway specific for METTL3, implicated in the maintenance of the leukaemic state. We identify METTL3 as an ess...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Barbieri, Isaia, Tzelepis, Konstantinos, Pandolfini, Luca, Shi, Junwei, Millán-Zambrano, Gonzalo, Robson, Samuel C., Aspris, Demetrios, Migliori, Valentina, Bannister, Andrew J., Han, Namshik, De Braekeleer, Etienne, Ponstingl, Hannes, Hendrick, Alan, Vakoc, Christopher R., Vassiliou, George S., Kouzarides, Tony
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217924/
https://ncbi.nlm.nih.gov/pubmed/29186125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24678
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