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MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo

Previous work has shown that synthesized siRNA/miRNA is tightly associated with RNA-induced Gene Silencing Complexes (RISCs) in vitro. However, it is unknown if the endogenous miRNAs are also stably bound to RISC complexes in vivo in cells under physiological conditions. Here we describe the use of...

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Dades bibliogràfiques
Publicat a:Biochem Biophys Res Commun
Autors principals: Tang, Fuchou, Hajkova, Petra, O’Carroll, Dónal, Lee, Caroline, Tarakhovsky, Alexander, Lao, Kaiqin, Surani, M. Azim
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612963/
https://ncbi.nlm.nih.gov/pubmed/18474225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.04.137
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