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MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo

Previous work has shown that synthesized siRNA/miRNA is tightly associated with RNA-induced Gene Silencing Complexes (RISCs) in vitro. However, it is unknown if the endogenous miRNAs are also stably bound to RISC complexes in vivo in cells under physiological conditions. Here we describe the use of...

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Bibliografiske detaljer
Udgivet i:Biochem Biophys Res Commun
Main Authors: Tang, Fuchou, Hajkova, Petra, O’Carroll, Dónal, Lee, Caroline, Tarakhovsky, Alexander, Lao, Kaiqin, Surani, M. Azim
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612963/
https://ncbi.nlm.nih.gov/pubmed/18474225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.04.137
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