MicroRNAs are tightly associated with RNA-induced gene silencing complexes in vivo

Previous work has shown that synthesized siRNA/miRNA is tightly associated with RNA-induced Gene Silencing Complexes (RISCs) in vitro. However, it is unknown if the endogenous miRNAs are also stably bound to RISC complexes in vivo in cells under physiological conditions. Here we describe the use of...

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Detalles Bibliográficos
Publicado en:Biochem Biophys Res Commun
Main Authors: Tang, Fuchou, Hajkova, Petra, O’Carroll, Dónal, Lee, Caroline, Tarakhovsky, Alexander, Lao, Kaiqin, Surani, M. Azim
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612963/
https://ncbi.nlm.nih.gov/pubmed/18474225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.04.137
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