Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK Biobank and genetic consortia participants: A Mendelian randomization study

BACKGROUND & AIMS: Arachidonic acid (AA) is metabolized by cyclooxygenases and lipoxygenases to pro-inflammatory eicosanoids, which according to experimental research modulate tumor cell proliferation, differentiation, and apoptosis. We employed the Mendelian randomization design to test the hyp...

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Vydáno v:Clin Nutr
Hlavní autoři: Larsson, Susanna C., Carter, Paul, Vithayathil, Mathew, Mason, Amy M., Michaёlsson, Karl, Baron, John A., Burgess, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612929/
https://ncbi.nlm.nih.gov/pubmed/33199044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clnu.2020.11.004
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