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Surface-tension-induced budding drives alveologenesis in human mammary gland organoids

Organ development involves complex shape transformations driven by active mechanical stresses that sculpt the growing tissue (1,2). Epithelial gland morphogenesis is a prominent example where cylindrical branches transform into spherical alveoli during growth(3–5). Here we show that this shape trans...

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Détails bibliographiques
Publié dans:Nat Phys
Auteurs principaux: Fernández, Pablo A., Buchmann, Benedikt, Goychuk, Andriy, Engelbrecht, Lisa K., Raich, Marion K., Scheel, Christina H., Frey, Erwin, Bausch, Andreas R.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612858/
https://ncbi.nlm.nih.gov/pubmed/35721781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41567-021-01336-7
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