Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer

Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer (PCa), cancer-associated fibroblasts are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, how lactate impacts transcriptional regulation in tu...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ippolito, Luigi, Comito, Giuseppina, Parri, Matteo, Iozzo, Marta, Duatti, Assia, Virgilio, Francesca, Lorito, Nicla, Bacci, Marina, Pardella, Elisa, Sandrini, Giada, Bianchini, Francesca, Damiano, Roberta, Ferrone, Lavinia, la Marca, Giancarlo, Serni, Sergio, Spatafora, Pietro, Catapano, Carlo V, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612586/
https://ncbi.nlm.nih.gov/pubmed/35135811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-0914
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