Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA

CRISPR-Cas systems store fragments of foreign DNA called spacers as immunological recordings used to combat future infections. Of the many spacers stored in a CRISPR array, the newest spacers are known to be prioritized for immune defense. However, the underlying mechanism remains unclear. Here we s...

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Vydáno v:Nat Microbiol
Hlavní autoři: Liao, Chunyu, Sharma, Sahil, Svensson, Sarah L., Kibe, Anuja, Weinberg, Zasha, Alkhnbashi, Omer S., Bischler, Thorsten, Backofen, Rolf, Caliskan, Neva, Sharma, Cynthia M., Beisel, Chase L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2022
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612570/
https://ncbi.nlm.nih.gov/pubmed/35314780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-022-01074-3
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