A non-invasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo(†)

Genetically encoded probes are widely used to visualize cellular processes in vitro and in vivo. Although effective in cultured cells, fluorescent protein tags and reporters are sub-optimal in vivo due to poor tissue penetration and high background signal. Luciferase reporters offer improved signal-...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Humpton, Timothy J, Hock, Andreas K, Kiourtis, Christos, Donatis, Marco De, Fercoq, Frederic, Nixon, Colin, Bryson, Sheila, Strathdee, Douglas, Carlin, Leo M., Bird, Thomas G., Blyth, Karen, Vousden, Karen H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612476/
https://ncbi.nlm.nih.gov/pubmed/35133863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abd9099
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