An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation of circulating tumor cells (CTC), and adaptation in various distant metastatic sites. The genes orchestrating each of these steps are poorly...

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Publicat a:Cancer Res
Autors principals: Scheidmann, Manuel C., Castro-Giner, Francesc, Strittmatter, Karin, Krol, Ilona, Paasinen-Sohns, Aino, Scherrer, Ramona, Donato, Cinzia, Gkountela, Sofia, Szczerba, Barbara M., Diamantopoulou, Zoi, Muenst, Simone, Vlajnic, Tatjana, Kunz, Leo, Vetter, Marcus, Rochlitz, Christoph, Taylor, Verdon, Giachino, Claudio, Schroeder, Timm, Platt, Randall J., Aceto, Nicola
Format: Artigo
Idioma:Inglês
Publicat: American Association for Cancer Research 2022
Matèries:
Tumor Biology and Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612409/
https://ncbi.nlm.nih.gov/pubmed/34916221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-21-3908
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