Evolution of virus-like protein architecture and genome packaging mechanisms in a repurposed bacterial enzyme

Viruses are ubiquitous pathogens of global impact. Prompted by the hypothesis that their earliest progenitors recruited host proteins for virion formation, we have used stringent laboratory evolution to convert a bacterial enzyme lacking affinity for nucleic acids into an artificial nucleocapsid tha...

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Udgivet i:Science
Main Authors: Tetter, Stephan, Terasaka, Naohiro, Steinauer, Angela, Bingham, Richard J., Clark, Sam, Scott, Andrew P., Patel, Nikesh, Leibundgut, Marc, Wroblewski, Emma, Ban, Nenad, Stockley, Peter G., Twarock, Reidun, Hilvert, Donald
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612296/
https://ncbi.nlm.nih.gov/pubmed/34112695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abg2822
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