Requirement for LIM kinases in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive disease for which only few targeted therapies are available. Using high-throughput RNA interference (RNAi) screening in AML cell lines, we identified LIM kinase 1 (LIMK1) as a potential novel target for AML treatment. High LIMK1 expression was significan...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Jensen, Patrizia, Carlet, Michela, Schlenk, Richard F., Weber, Andrea, Kress, Jana, Brunner, Ines, Słabicki, Mikołaj, Grill, Gregor, Weisemann, Simon, Cheng, Ya-Yun, Jeremias, Irmela, Scholl, Claudia, Fröhling, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612252/
https://ncbi.nlm.nih.gov/pubmed/32591645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0943-5
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