Enhancers predominantly regulate gene expression during differentiation via transcription initiation

Gene transcription occurs via a cycle of linked events including initiation, promoter proximal pausing and elongation of RNA polymerase II (Pol II). A key question is how do transcriptional enhancers influence these events to control gene expression? Here we present an approach, which evaluates the...

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Pubblicato in:Mol Cell
Autori principali: Larke, Martin S. C., Schwessinger, Ron, Nojima, Takayuki, Telenius, Jelena, Beagrie, Robert A., Downes, Damien J., Oudelaar, A. Marieke, Truch, Julia, Graham, Bryony, Bender, M. A., Proudfoot, Nicholas J., Higgs, Douglas R., Hughes, Jim R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612206/
https://ncbi.nlm.nih.gov/pubmed/33539786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.002
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