Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non-small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and anti-angiogenic drugs may improve the efficacy of ICB in mo...

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Vydáno v:Sci Transl Med
Hlavní autoři: Martinez-Usatorre, Amaia, Kadioglu, Ece, Boivin, Gael, Cianciaruso, Chiara, Guichard, Alan, Torchia, Bruno, Zangger, Nadine, Nassiri, Sina, Keklikoglou, Ioanna, Schmittnaegel, Martina, Ries, Carola H., Meylan, Etienne, De Palma, Michele
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612153/
https://ncbi.nlm.nih.gov/pubmed/34380768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd1616
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