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Ring Expansion of 1-Indanones to 2-Halo-1-naphthols as an Entry Point to Gilvocarcin Natural Products

[Image: see text] Herein, we describe a two-step ring expansion of 1-indanones to afford 2-chloro/bromo-1-naphthols (32 examples). The developed method shows broad functional group tolerance, benefits from mild reaction conditions, and enables rapid access to the tetracyclic core of gilvocarcin natu...

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Bibliographic Details
Published in:Org Lett
Main Authors: Zamarija, Ivica, Marsh, Benjamin J., Magauer, Thomas
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612072/
https://ncbi.nlm.nih.gov/pubmed/34780199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.1c03530
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