Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

The longitudinal dynamics of the most promising biofluid biomarker candidates for Huntington’s disease (HD)— mutant huntingtin (mHTT) and neurofilament light (NfL)—are incompletely defined. Characterizing changes in these candidates during disease progression could increase our understanding of dise...

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Pubblicato in:Sci Transl Med
Autori principali: Rodrigues, Filipe B., Byrne, Lauren M., Tortelli, Rosanna, Johnson, Eileanoir B., Wijeratne, Peter A., Arridge, Marzena, De Vita, Enrico, Ghazaleh, Naghmeh, Houghton, Richard, Furby, Hannah, Alexander, Daniel C., Tabrizi, Sarah J., Schobel, Scott, Scahill, Rachael I., Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611886/
https://ncbi.nlm.nih.gov/pubmed/33328328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abc2888
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