Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

The longitudinal dynamics of the most promising biofluid biomarker candidates for Huntington’s disease (HD)— mutant huntingtin (mHTT) and neurofilament light (NfL)—are incompletely defined. Characterizing changes in these candidates during disease progression could increase our understanding of dise...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Rodrigues, Filipe B., Byrne, Lauren M., Tortelli, Rosanna, Johnson, Eileanoir B., Wijeratne, Peter A., Arridge, Marzena, De Vita, Enrico, Ghazaleh, Naghmeh, Houghton, Richard, Furby, Hannah, Alexander, Daniel C., Tabrizi, Sarah J., Schobel, Scott, Scahill, Rachael I., Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611886/
https://ncbi.nlm.nih.gov/pubmed/33328328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abc2888
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