Effector differentiation downstream of lineage commitment in ILC1 is driven by Hobit across tissues

Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation and early immunity against infection. It is unclear how ILCs acquire effector function, and whether these mechanisms differ between organs. Through multiplexed single-cell mRNA-sequencing we identified cKit(+)CD127(hi)TCF-1...

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Publicado no:Nat Immunol
Main Authors: Friedrich, Christin, Taggenbrock, Renske L. R. E., Doucet-Ladevèze, Rémi, Golda, Gosia, Moenius, Rebekka, Arampatzi, Panagiota, Kragten, Natasja A. M., Kreymborg, Katharina, de Agüero, Mercedes Gomez, Kastenmueller, Wolfgang, Saliba, Antoine-Emmanuel, Grün, Dominic, van Gisbergen, Klaas P. J. M., Gasteiger, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611762/
https://ncbi.nlm.nih.gov/pubmed/34462601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01013-0
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