MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation

The antiviral cytokine interferon (IFN) activates expression of IFN-stimulated genes (ISGs) to establish an antiviral state. Myxovirus resistance 2 (MX2/MxB) is an ISG that inhibits the nuclear import of HIV-1 and interacts with the viral capsid and cellular nuclear transport machinery. We identifie...

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Bibliografische gegevens
Gepubliceerd in:Nat Microbiol
Hoofdauteurs: Betancor, Gilberto, Jimenez-Guardeño, Jose M, Lynham, Steven, Antrobus, Robin, Khan, Hataf, Sobala, Andrew, Dicks, Matthew DJ, Malim, Michael H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611661/
https://ncbi.nlm.nih.gov/pubmed/34282309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-021-00937-5
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