Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the precise mechanism of viral inhibition remains unclear, MX2 is localized to the nuclear envelope, and blocks the nuclear import of viral cDNAs. The...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Dicks, Matthew D. J., Betancor, Gilberto, Jimenez-Guardeño, Jose M., Pessel-Vivares, Lucie, Apolonia, Luis, Goujon, Caroline, Malim, Michael H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264145/
https://ncbi.nlm.nih.gov/pubmed/30496303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007408
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