Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia

Chronic Lymphocytic Leukemia (CLL) has a complex pattern of driver mutations and much of its clinical diversity remains unexplained. We devised a method for simultaneous subgroup discovery across multiple data types and applied it to genomic, transcriptomic, DNA methylation and ex-vivo drug response...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Cancer
Prif Awduron: Lu, Junyan, Cannizzaro, Ester, Meier-Abt, Fabienne, Scheinost, Sebastian, Bruch, Peter-Martin, Giles, Holly AR, Lütge, Almut, Hüllein, Jennifer, Wagner, Lena, Giacopelli, Brian, Nadeu, Ferran, Delgado, Julio, Campo, Elías, Mangolini, Maurizio, Ringshausen, Ingo, Böttcher, Martin, Mougiakakos, Dimitrios, Jacobs, Andrea, Bodenmiller, Bernd, Dietrich, Sascha, Oakes, Christopher C., Zenz, Thorsten, Huber, Wolfgang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611543/
https://ncbi.nlm.nih.gov/pubmed/34423310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-021-00216-6
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