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IGLV3-21(R110) identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics
B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology. IGLV3-21–expressing B cells may acquire a single point mutation (R110) that triggers autonomous BCR signaling, conferring aggressive behavior. Epigenetic studies have defined 3 CLL subtypes based on methylatio...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8191863/ https://ncbi.nlm.nih.gov/pubmed/33211804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008311 |
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