IGLV3-21(R110) identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics

B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology. IGLV3-21–expressing B cells may acquire a single point mutation (R110) that triggers autonomous BCR signaling, conferring aggressive behavior. Epigenetic studies have defined 3 CLL subtypes based on methylatio...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Nadeu, Ferran, Royo, Romina, Clot, Guillem, Duran-Ferrer, Martí, Navarro, Alba, Martín, Silvia, Lu, Junyan, Zenz, Thorsten, Baumann, Tycho, Jares, Pedro, Puente, Xose S., Martín-Subero, José I., Delgado, Julio, Campo, Elías
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191863/
https://ncbi.nlm.nih.gov/pubmed/33211804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008311
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