Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer

In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes. Here, we investigated B lymphocyte subsets, immunoglobulin expression, and clonal features in breast tumors, focusing on aggressive triple-negative breast cancers (TNBC). In sampl...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Harris, Robert J., Cheung, Anthony, Ng, Joseph C.F., Laddach, Roman, Chenoweth, Alicia M., Crescioli, Silvia, Fittall, Matthew, Dominguez-Rodriguez, Diana, Roberts, James, Levi, Dina, Liu, Fangfang, Alberts, Elena, Quist, Jelmar, Santaolalla, Aida, Pinder, Sarah E., Gillett, Cheryl, Hammar, Niklas, Irshad, Sheeba, Van Hemelrijck, Mieke, Dunn-Walters, Deborah K., Fraternali, Franca, Spicer, James F., Lacy, Katie E., Tsoka, Sophia, Grigoriadis, Anita, Tutt, Andrew N.J., Karagiannis, Sophia N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for Cancer Research 2021
Schlagworte:
Tumor Biology and Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611538/
https://ncbi.nlm.nih.gov/pubmed/34224371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-3773
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