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Structure of the shutdown state of myosin-2

Myosin-2 is essential for processes as diverse as cell division and muscle contraction. Dephosphorylation of its regulatory light chain (RLC) promotes an inactive, ‘shutdown’ state with the filament-forming tail folded onto the two heads(1), preventing filament formation and inactivating the motors(...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Scarff, Charlotte A, Carrington, Glenn, Casas-Mao, David, Chalovich, Joseph M, Knight, Peter J, Ranson, Neil A, Peckham, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611489/
https://ncbi.nlm.nih.gov/pubmed/33268888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2990-5
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