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Cardiomyopathy Mutations in the Tail of β-Cardiac Myosin Modify the Coiled-coil Structure and Affect Integration into Thick Filaments in Muscle Sarcomeres in Adult Cardiomyocytes

It is unclear why mutations in the filament-forming tail of myosin heavy chain (MHC) cause hypertrophic or dilated cardiomyopathy as these mutations should not directly affect contraction. To investigate this, we first investigated the impact of five hypertrophic cardiomyopathy-causing (N1327K, E135...

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Bibliografiske detaljer
Main Authors: Wolny, Marcin, Colegrave, Melanie, Colman, Lucy, White, Ed, Knight, Peter J., Peckham, Michelle
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814791/
https://ncbi.nlm.nih.gov/pubmed/24047955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513291
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