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Cardiomyopathy Mutations in the Tail of β-Cardiac Myosin Modify the Coiled-coil Structure and Affect Integration into Thick Filaments in Muscle Sarcomeres in Adult Cardiomyocytes

It is unclear why mutations in the filament-forming tail of myosin heavy chain (MHC) cause hypertrophic or dilated cardiomyopathy as these mutations should not directly affect contraction. To investigate this, we first investigated the impact of five hypertrophic cardiomyopathy-causing (N1327K, E135...

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מידע ביבליוגרפי
Main Authors: Wolny, Marcin, Colegrave, Melanie, Colman, Lucy, White, Ed, Knight, Peter J., Peckham, Michelle
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814791/
https://ncbi.nlm.nih.gov/pubmed/24047955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513291
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