Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients

Low-affinity CD19 chimeric antigen receptor (CAR) T cells display enhanced expansion and persistence, enabling fate tracking through integration site analysis. Here we show that integration sites from early (1 month) and late (>3yr) timepoints cluster separately, suggesting different clonal contr...

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Pubblicato in:Nat Cancer
Autori principali: Biasco, Luca, Izotova, Natalia, Rivat, Christine, Ghorashian, Sara, Richardson, Rachel, Guvenel, Aleks, Hough, Rachael, Wynn, Robert, Popova, Bilyana, Lopes, Andre, Pule, Martin, Thrasher, Adrian J., Amrolia, Persis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611448/
https://ncbi.nlm.nih.gov/pubmed/34345830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-021-00207-7
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