TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Chimeric antigen receptor (CAR)–expressing T cells induce durable remissions in patients with relapsed/refractory B cell malignancies. CARs are synthetic constructs that, when introduced into mature T cells, confer a second, non–major histocompatibility complex–restricted specificity in addition to...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Yang, Yinmeng, Kohler, M. Eric, Chien, Christopher D., Sauter, Christopher T., Jacoby, Elad, Yan, Chunhua, Hu, Ying, Wanhainen, Kelsey, Qin, Haiying, Fry, Terry J.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944272/
https://ncbi.nlm.nih.gov/pubmed/29167392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1209
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