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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance
Chimeric antigen receptor (CAR)–expressing T cells induce durable remissions in patients with relapsed/refractory B cell malignancies. CARs are synthetic constructs that, when introduced into mature T cells, confer a second, non–major histocompatibility complex–restricted specificity in addition to...
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| Publicado no: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6944272/ https://ncbi.nlm.nih.gov/pubmed/29167392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1209 |
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