Bispecific antibodies enable synthetic agonistic receptor-transduced T cells for tumor immunotherapy

BACKGROUND: Genetically engineered T cells are powerful anti-cancer treatments but are limited by safety and specificity issues. We herein describe a MHC-unrestricted modular platform combining autologous T cells, transduced with a targetable synthetic agonistic receptor (SAR), with bispecific antib...

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Udgivet i:Clin Cancer Res
Main Authors: Karches, Clara H., Benmebarek, Mohamed-Reda, Schmidbauer, Moritz L., Kurzay, Mathias, Klaus, Richard, Geiger, Martina, Rataj, Felicitas, Cadilha, Bruno L., Lesch, Stefanie, Heise, Constanze, Murr, Ramona, Berg, Johannes vom, Jastroch, Martin, Lamp, Daniel, Ding, Jian, Duewell, Peter, Niederfellner, Gerhard, Sustmann, Claudio, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611266/
https://ncbi.nlm.nih.gov/pubmed/31285373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3927
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