The peroxisomal fatty acid transporter pmp-4 is required in the C. elegans hypodermis for axonal maintenance

Adrenoleukodystrophy is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). Its pathogenesis is incompletely understood. Here we characterize a nematode model of X-ALD with loss of the pmp-4 gene, the worm orthologue of ABCD1. These...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Coppa, Andrea, Guha, Sanjib, Fourcade, Stéphane, Parameswaran, Janani, Ruiz, Montserrat, Moser, Ann, Schlüter, Agatha, Murphy, Michael P., Lizcano, Jose Miguel, Miranda-Vizuete, Antonio, Dalfó, Esther, Pujol, Aurora
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611262/
https://ncbi.nlm.nih.gov/pubmed/32017990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.01.177
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