EZH2 deficient T-cell acute lymphoblastic leukemia is sensitized to CHK1 inhibition through enhanced replication stress

Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (TALL). Using isogenic T-ALL cells, with and without CRISPR/Cas9-induced EZH2-inactivating mutations, we performed a cell-bas...

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Publicado no:Cancer Discov
Main Authors: León, Theresa E., Rapoz-D’Silva, Tanya, Bertoli, Cosetta, Rahman, Sunniyat, Magnussen, Michael, Philip, Brian, Farah, Nadine, Richardson, Simon E., Ahrabi, Sara, Guerra-Assunção, José Afonso, Gupta, Rajeev, Nacheva, Elisabeth P., Henderson, Stephen, Herrero, Javier, Linch, David C., de Bruin, Robertus A., Mansour, Marc R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611258/
https://ncbi.nlm.nih.gov/pubmed/32349972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0789
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