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Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues

In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput. Here we combine the CUT&Tag technology, developed to measure bulk histone modifications, with droplet-...

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: Bartosovic, Marek, Kabbe, Mukund, Castelo-Branco, Gonçalo
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611252/
https://ncbi.nlm.nih.gov/pubmed/33846645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-021-00869-9
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