Functional human IgA targets a conserved site on malaria sporozoites

Immunoglobulin (Ig)A antibodies play a critical role in protection against mucosal pathogens. However, the role of serum IgA in immunity to non-mucosal pathogens, such as Plasmodium falciparum, is poorly characterized, despite being the second most abundant isotype in blood after IgG. Here, we inves...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Tan, Joshua, Cho, Hyeseon, Pholcharee, Tossapol, Pereira, Lais S., Doumbo, Safiatou, Doumtabe, Didier, Flynn, Barbara J., Schön, Arne, Kanatani, Sachie, Aylor, Samantha O., Oyen, David, Vistein, Rachel, Wang, Lawrence, Dillon, Marlon, Skinner, Jeff, Peterson, Mary, Li, Shanping, Idris, Azza H., Molina-Cruz, Alvaro, Zhao, Ming, Olano, Lisa Renee, Lee, Patricia J., Roth, Alison, Sinnis, Photini, Barillas-Mury, Carolina, Kayentao, Kassoum, Ongoiba, Aissata, Francica, Joseph R., Traore, Boubacar, Wilson, Ian A., Seder, Robert A., Crompton, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611206/
https://ncbi.nlm.nih.gov/pubmed/34162751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abg2344
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