Modified Hypoxia-Inducible Factor Expression in CD8(+) T Cells Increases Antitumor Efficacy

Adoptive transfer of antitumor cytotoxic T cells is an emerging form of cancer immunotherapy. A key challenge to expanding the utility of adoptive-cell therapies is how to enhance the survival and function of the transferred T cells. Immune-cell survival requires adaptation to different microenviron...

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Bibliographic Details
Published in:Cancer Immunol Res
Main Authors: Veliça, Pedro, Cunha, Pedro P., Vojnovic, Nikola, Foskolou, Iosifina Petrina, Bargiela, David, Gojkovic, Milos, Rundqvist, Helene, Johnson, Randall S.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611205/
https://ncbi.nlm.nih.gov/pubmed/33602720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0561
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