Matrix-targeting immunotherapy controls tumor growth and spread by switching macrophage phenotype

The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immuno-modulatory properties of the extracellular matrix to create a microenvironment that enables their escape from immune surveillance. Using orthotopic grafting of...

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Pubblicato in:Cancer Immunol Res
Autori principali: Deligne, Claire, Murdamoothoo, Devadarssen, Gammage, Anis N., Gschwandtner, Martha, Erne, William, Loustau, Thomas, Marzeda, Anna M., Carapito, Raphael, Paul, Nicodème, Velazquez-Quesada, Inés, Mazzier, Imogen, Sun, Zhen, Orend, Gertraud, Midwood, Kim S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611136/
https://ncbi.nlm.nih.gov/pubmed/31941671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0276
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