A cell atlas of human thymic development defines T cell repertoire formation

The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell dif...

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Publicat a:Science
Autors principals: Park, Jong-Eun, Botting, Rachel A., Conde, Cecilia Domínguez, Popescu, Dorin-Mirel, Lavaert, Marieke, Kunz, Daniel J., Goh, Issac, Stephenson, Emily, Ragazzini, Roberta, Tuck, Elizabeth, Wilbrey-Clark, Anna, Roberts, Kenny, Kedlian, Veronika R., Ferdinand, John R., He, Xiaoling, Webb, Simone, Maunder, Daniel, Vandamme, Niels, Mahbubani, Krishnaa T., Polanski, Krzysztof, Mamanova, Lira, Bolt, Liam, Crossland, David, de Rita, Fabrizio, Fuller, Andrew, Filby, Andrew, Reynolds, Gary, Dixon, David, Saeb-Parsy, Kourosh, Lisgo, Steven, Henderson, Deborah, Vento-Tormo, Roser, Bayraktar, Omer A., Barker, Roger A., Meyer, Kerstin B., Saeys, Yvan, Bonfanti, Paola, Behjati, Sam, Clatworthy, Menna R., Taghon, Tom, Haniffa, Muzlifah, Teichmann, Sarah A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611066/
https://ncbi.nlm.nih.gov/pubmed/32079746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay3224
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