Mitochondrial oxidative damage underlies regulatory T cell defects in autoimmunity

Regulatory T (Treg) cells are vital for the maintenance of immune homeostasis, while their dysfunction constitutes a cardinal feature of autoimmunity. Under steady state conditions, mitochondrial metabolism is critical for Treg function; however, the metabolic adaptations of Tregsduring autoimmunity...

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Vydáno v:Cell Metab
Hlavní autoři: Alissafi, Themis, Kalafati, Lydia, Lazari, Maria, Filia, Anastasia, Kloukina, Ismini, Manifava, Maria, Lim, Jong-Hyung, Alexaki, Vasileia Ismini, Ktistakis, Nicholas T., Doskas, Triantafyllos, Garinis, George A., Chavakis, Triantafyllos, Boumpas, Dimitrios T., Verginis, Panayotis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611060/
https://ncbi.nlm.nih.gov/pubmed/32738205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.07.001
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