In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Base editors are RNA-programmable deaminases enabling precise single-base conversions on genomic DNA. However, off-target activity is a concern in the potential use of base editors to treat genetic diseases. Here, we report unbiased analyses of transcriptome-wide and genome-wide off-target modificat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Villiger, Lukas, Rothgangl, Tanja, Witzigmann, Dominik, Oka, Rurika, Lin, Paulo J.C., Qi, Weihong, Janjuha, Sharan, Berk, Christian, Ringnalda, Femke, Beattie, Mitchell B., Stoffel, Markus, Thöny, Beat, Hall, Jonathan, Rehrauer, Hubert, van Boxtel, Ruben, Tam, Ying K., Schwank, Gerald
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610981/
https://ncbi.nlm.nih.gov/pubmed/33495639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-00671-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados