MAIT cell activation augments adenovirus vector vaccine immunogenicity*

Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized MAIT cells may have inherent adjuvant activity in vaccine platforms that employ replication-incompetent adenovirus vectors. In mice and human...

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Vydáno v:Science
Hlavní autoři: Provine, Nicholas M., Amini, Ali, Garner, Lucy C., Spencer, Alexandra J., Dold, Christina, Hutchings, Claire, Reyes, Laura Silva, FitzPatrick, Michael E.B., Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Ulaszewska, Marta, Troise, Fulvia, Sharpe, Hannah, Morgan, Sophie B., Hinks, Timothy S.C., Lambe, Teresa, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S., Pollard, Andrew J., Klenerman, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610941/
https://ncbi.nlm.nih.gov/pubmed/33510029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax8819
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