Prokaryotic viperins produce diverse antiviral molecules

Viperin is an interferon-induced cellular protein conserved in animals. It was shown to inhibit the replication of multiple viruses by producing a ribonucleotide called 3’-deoxy-3’4’-didehydro-CTP (ddhCTP), which acts as a chain terminator for the viral RNA polymerase. Here we show that the eukaryot...

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Vydáno v:Nature
Hlavní autoři: Bernheim, Aude, Millman, Adi, Ofir, Gal, Meitav, Gilad, Avraham, Carmel, Shomar, Helena, Rosenberg, Masha M., Tal, Nir, Melamed, Sarah, Amitai, Gil, Sorek, Rotem
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610908/
https://ncbi.nlm.nih.gov/pubmed/32937646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2762-2
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