Metabolic Reprogramming of Terminally Exhausted CD8(+) T cells by IL-10 Enhances Anti-Tumor Immunity

T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8(+) tumor-infiltrating lymphocytes (TILs), the terminally exhausted subset contributes directly to tumor cell killing owing to its cytotoxic effector function. However, this subset does not respond to imm...

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Pubblicato in:Nat Immunol
Autori principali: Guo, Yugang, Xie, Yu-Qing, Gao, Min, Zhao, Yang, Franco, Fabien, Wenes, Mathias, Siddiqui, Imran, Bevilacqua, Alessio, Wang, Haiping, Yang, Hanshuo, Feng, Bing, Xie, Xin, Sabatel, Catherine M., Tschumi, Benjamin, Chaiboonchoe, Amphun, Wang, Yuxi, Li, Weimin, Xiao, Weihua, Held, Werner, Romero, Pedro, Ho, Ping-Chih, Tang, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610876/
https://ncbi.nlm.nih.gov/pubmed/34031618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00940-2
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