Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia

BACKGROUND: The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor–blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeli...

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Udgivet i:N Engl J Med
Main Authors: Brannan, Stephen K., Sawchak, Sharon, Miller, Andrew C., Lieberman, Jeffrey A., Paul, Steven M., Breier, Alan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610870/
https://ncbi.nlm.nih.gov/pubmed/33626254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2017015
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